mortality/aging
• shorter lifespan (15.9 months) compared to controls (20.5 months)
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neoplasm
• 89.5% tumor incidence compared to 44.4% in controls, with some developing multiple cancers
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• 32% developed lymphomas, mainly histiocytic sarcomas
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• 63% developed sarcomas, mainly hemangiosarcomas
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cellular
• trisomy and tetrasomy of chromosome 6 and duplication of the mutant Met allele were observed in tumors
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immune system
• infrequent to moderate incidence of glomerulonephritis
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renal/urinary system
• infrequent to moderate incidence of glomerulonephritis
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• infrequent to moderate incidence of hydronephrosis
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