Phenotypes Associated with This Genotype

Genotype
MGI:3525206

• Allelic Composition: Cblb^tm1Hua/Cblb^tm1Hua
• Genetic Background: B6.129P2-Cblb^tm1Hua

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:94685 )

• mutant T cells are hypersensitive to anti-CD3 stimulated proliferation

• this increase is more pronounced than in B6.129X1-Stk17b^tm1Hed homozygotes

increased interleukin-2 secretion ( J:94685 )

• more IL-2 is produced by nave T cells in response to anti-CD3 stimulation

• this increase is more pronounced than in B6.129X1-Stk17b^tm1Hed homozygotes

increased susceptibility to experimental autoimmune encephalomyelitis ( J:94685 )

• both the incidence and severity of experimental autoimmune encephalomyelitis are increased in mutants

hematopoietic system

increased T cell proliferation ( J:94685 )

• mutant T cells are hypersensitive to anti-CD3 stimulated proliferation

• this increase is more pronounced than in B6.129X1-Stk17b^tm1Hed homozygotes

cellular

increased T cell proliferation ( J:94685 )

• mutant T cells are hypersensitive to anti-CD3 stimulated proliferation

• this increase is more pronounced than in B6.129X1-Stk17b^tm1Hed homozygotes