Phenotypes Associated with This Genotype

Genotype
MGI:3526259

• Allelic Composition: Plcl1^tm1Mh/Plcl1^tm1Mh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to xenobiotic ( J:92489 )

• at low doses (1 mg/kg) diazepam does not induce a sedative effect in homozygous mutants, however at high doses (3.2 mg/kg) a sedative effect is seen in mutants and wild-type mice

abnormal motor coordination/balance ( J:92489 )

• mutants fall more often and earlier in a rotarod test

nervous system

abnormal nervous system electrophysiology ( J:92489 )

• Zn²⁺ fails to inhibit and diazepam fails to potentiate GABA_A receptor-mediated Cl^- currents in mutant hippocampal neurons unlike in wild-type