Phenotypes Associated with This Genotype

Genotype
MGI:3526813

• Allelic Composition: Plcl1^tm1Mh/Plcl1^tm1Mh
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:92956 )

• increased mortality rate after PTZ (at 56 mg/kg) induced seizures compared to wild-type

behavior/neurological

seizures ( J:92956 )

• mutants do not develop spontaneous behavior seizure

increased susceptibility to pharmacologically induced seizures ( J:92956 )

• homozygous mutants were more susceptible to pentylenetetrazol (PTZ) induced convulsion

• homozygous mutants have shorter latencies until the first clonic convulsion and tonic extensor and increased incidence of convulsion than wild-type following PTZ administration

nervous system

seizures ( J:92956 )

• mutants do not develop spontaneous behavior seizure

increased susceptibility to pharmacologically induced seizures ( J:92956 )

• homozygous mutants were more susceptible to pentylenetetrazol (PTZ) induced convulsion

• homozygous mutants have shorter latencies until the first clonic convulsion and tonic extensor and increased incidence of convulsion than wild-type following PTZ administration

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:92956 )

• increased mortality rate after PTZ (at 56 mg/kg) induced seizures compared to wild-type