Phenotypes Associated with This Genotype

Genotype
MGI:3527458

• Allelic Composition: Zbtb32^tm2Ppp/Zbtb32^tm2Ppp
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased T cell proliferation ( J:95119 )

• alphaCD3 antibody-induced CD3+ T lymphocyte proliferation is increased in homozygotes

abnormal definitive hematopoiesis ( J:95119 )

• more cells in the hematopoietic stem cells/early progenitor pool have entered the cell cycle

immune system

increased T cell proliferation ( J:95119 )

• alphaCD3 antibody-induced CD3+ T lymphocyte proliferation is increased in homozygotes

abnormal cytokine secretion ( J:95119 )

• CD8+ T cells stimulated under neutral conditions produce more Ifng and CD4+ T cells stimulated under T-helper 2 skewing conditions produce more IL-4, IL-5, and IL-13

cellular

increased T cell proliferation ( J:95119 )

• alphaCD3 antibody-induced CD3+ T lymphocyte proliferation is increased in homozygotes