Phenotypes Associated with This Genotype

Genotype
MGI:3527483

• Allelic Composition: Parg^tm1Tmd/Parg^tm1Tmd
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:95214 )

• homozygous embryos are alive at E3.5 but fail to hatch, degenerate, and die before E6.5

cellular

increased apoptosis ( J:95214 )

• in the absence of a broad spectrum PARP inhibitor mutant trophoblast stem cells display significantly increased apoptosis

decreased cell proliferation ( J:95214 )

• in the absence of a broad spectrum PARP inhibitor mutant trophoblast stem cells display significantly reduced proliferation

embryo

failure of blastocyst to hatch from the zona pellucida ( J:95214 )

• homozygous embryos fail to hatch from the zona pellucida