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Phenotypes Associated with This Genotype
Genotype
MGI:3527493
Allelic
Composition
Nr3c1tm2Gsc/Nr3c1tm2Gsc
Tg(Wap-cre)1Gsc/0
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Wap-cre)1Gsc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• between day 14.5 of pregnancy (P14.5) and P18.5, lobuloalveolar development was retarded, however milk protein expression is normal and females are able to nurse pups although pups weight 20% less during the first 10 days after birth
• decreased cell proliferation in P14.5 mammary glands and increased cell proliferation in lactating (L0.5) mammary glands, however did not observe any differences in apoptosis during pregnancy
• although secretory alveoli form, less space is occupied by epithelial structures and more space is occupied by fat compared to controls during pregnancy and throughout lactation indicating that alveolar lobes do not completely penetrate the mammary fat pad

reproductive system
• between day 14.5 of pregnancy (P14.5) and P18.5, lobuloalveolar development was retarded, however milk protein expression is normal and females are able to nurse pups although pups weight 20% less during the first 10 days after birth
• decreased cell proliferation in P14.5 mammary glands and increased cell proliferation in lactating (L0.5) mammary glands, however did not observe any differences in apoptosis during pregnancy

integument
• between day 14.5 of pregnancy (P14.5) and P18.5, lobuloalveolar development was retarded, however milk protein expression is normal and females are able to nurse pups although pups weight 20% less during the first 10 days after birth
• decreased cell proliferation in P14.5 mammary glands and increased cell proliferation in lactating (L0.5) mammary glands, however did not observe any differences in apoptosis during pregnancy
• although secretory alveoli form, less space is occupied by epithelial structures and more space is occupied by fat compared to controls during pregnancy and throughout lactation indicating that alveolar lobes do not completely penetrate the mammary fat pad


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory