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Phenotypes Associated with This Genotype
Genotype
MGI:3527579
Allelic
Composition		 Smad2tm3Rob/Smad2tm3Rob
Smad3tm1Xfw/Smad3tm1Xfw
Genetic
Background		 involves: 129/Sv * 129S/SvEv * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm3Rob mutation (2 available); any Smad2 mutation (52 available)
Smad3tm1Xfw mutation (0 available); any Smad3 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
osteoarthritis ( J:95374 )
• double homozygotes develop osteoarthritis similar to Smad3 single homozygotes but do not show any increase in mortality

skeleton
osteoarthritis ( J:95374 )
• double homozygotes develop osteoarthritis similar to Smad3 single homozygotes but do not show any increase in mortality

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory