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Phenotypes Associated with This Genotype
Genotype
MGI:3528380
Allelic
Composition		 Cblbtm1Pngr/Cblbtm1Pngr
Vav1tm1Tyb/Vav1tm1Tyb
Wastm1Sbs/Wastm1Sbs
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Pngr mutation (6 available); any Cblb mutation (58 available)
Vav1tm1Tyb mutation (2 available); any Vav1 mutation (60 available)
Wastm1Sbs mutation (2 available); any Was mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:79550 )
• introduction of the Cblbtm1Pngr mutation into a Wastm1Sbs/Vav1tm1Tyb double null background fails to restore T cell responses and receptor clustering, indicating that WAS protein is critical for deregulated proliferation and membrane receptor reorganization of Cblbtm1Pngr mutant T cells

hematopoietic system
abnormal T cell physiology ( J:79550 )
• introduction of the Cblbtm1Pngr mutation into a Wastm1Sbs/Vav1tm1Tyb double null background fails to restore T cell responses and receptor clustering, indicating that WAS protein is critical for deregulated proliferation and membrane receptor reorganization of Cblbtm1Pngr mutant T cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory