Phenotypes Associated with This Genotype

Genotype
MGI:3574577

• Allelic Composition: Phb2^tm1Katz/Phb2⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:96817 )

• the numbers of heterozygous mutants were underrepresented among weaned pups but did not observe death after birth, indicating that some embryos may have died during a late gestational stage

growth/size/body

increased susceptibility to weight gain ( J:96817 )

• heterozygous females exhibited a greater gain in body weight from 9 weeks of age to 26 weeks of age than in wildtype, but no differences in males

reproductive system

abnormal uterus morphology ( J:96817 )

♀ • the apical surface of the luminal epithelium in the uteri of estradiol treated females was more convoluted than the smooth apical surface in wildtype and showed luminal epithelium hyperproliferation

increased uterus weight ( J:96817 )

♀ • females treated with estradiol (E2) for 4 days had a 40% increase in uterine weight

abnormal litter size ( J:96817 )

• exhibited larger litter sizes than on the 129S6/SvEvTac coisogenic background

• litter sizes of second-generation mice were reduced significantly from those of the first-generation mice (5.9 vs 7.5 pups)