Phenotypes Associated with This Genotype

Genotype
MGI:3575009

• Allelic Composition: Foxn4^tm1Xia/Foxn4^tm1Xia
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:92622 )

• most mutant pups die during the early postnatal period

vision/eye

increased retina apoptosis ( J:92622 )

• apoptosis is increased at postnatal stages, especially in the ectopic projections of the outer nuclear layer

decreased amacrine cell number ( J:92622 )

• the number of amacrine cells is significantly reduced

• amacrine cells are not produced during early retinogenesis at E14.5 and E17.5

absent retina horizontal cells ( J:92622 )

• horizontal cells are absent at P8 and P20

• horizontal cells are not produced during early retinogenesis at E17.5

abnormal retina neuronal layer morphology ( J:92622 )

• at P8 and P20 the retinas are thinner than normal, particularly in the inner nuclear, inner plexiform, and ganglion cell layers

• at P20 the outer plexiform layer is absent, however the outer nuclear layer is thicker than normal and has ectopic projections

increased retina photoreceptor cell number ( J:92622 )

• expression of a marker for rods and cones is significantly increased

abnormal retina ganglion cell morphology ( J:92622 )

• retinal ganglion cells are abnormally located within the inner margin of the inner nuclear layer

retina hypoplasia ( J:92622 )

• abnormal retinal progenitor proliferation; proliferation of retinal progenitors is reduced about 25% at E15.5 and E17.5

nervous system

decreased amacrine cell number ( J:92622 )

• the number of amacrine cells is significantly reduced

• amacrine cells are not produced during early retinogenesis at E14.5 and E17.5

increased retina photoreceptor cell number ( J:92622 )

• expression of a marker for rods and cones is significantly increased

abnormal retina ganglion cell morphology ( J:92622 )

• retinal ganglion cells are abnormally located within the inner margin of the inner nuclear layer

absent retina horizontal cells ( J:92622 )

• horizontal cells are absent at P8 and P20

• horizontal cells are not produced during early retinogenesis at E17.5

cellular

increased retina apoptosis ( J:92622 )

• apoptosis is increased at postnatal stages, especially in the ectopic projections of the outer nuclear layer