Phenotypes Associated with This Genotype

Genotype
MGI:3575517

• Allelic Composition: Ifnar1^tm1Agt/Ifnar1^tm1Agt; Ifngr1^tm1Agt/Ifngr1^tm1Agt
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:115139 )

• all mice are killed at as little as 10 PFU of MCMV

immune system

immune system phenotype ( J:286237 )

N • mice infected with the Urbani strain of severe acute respiratory syndrome coronavirus (SARS-CoV) show no differences in susceptibility to infection from wild-type or single homozygous mice

abnormal immunoglobulin level ( J:101427 )

• levels of IgG2a and IgG2b neutralizing antibodies are reduced relative to controls after secondary infection with Ectromelia virus

increased susceptibility to Herpesvirales infection ( J:81243 )

• mice are 100,000-fold more susceptible to MCMV viral infection than controls

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:115139 )

• all mice are killed at as little as 10 PFU of MCMV

increased susceptibility to Poxviridae infection ( J:101427 )

• increased susceptibility to Ectromelia virus

• 100% mortality by day 6-12 after primary infection infection

• elevated virus titers in all organs tested after primary infection but much improved after secondary infections

• survive secondary infections

increased susceptibility to Togaviridae infection ( J:81243 )

• acutely sensitive to Sindbis viral infection; as little as one pfu will induce mortality as opposed to wild-type, which can withstand doses of 100,000 pfu

hematopoietic system

abnormal immunoglobulin level ( J:101427 )

• levels of IgG2a and IgG2b neutralizing antibodies are reduced relative to controls after secondary infection with Ectromelia virus