Phenotypes Associated with This Genotype

Genotype
MGI:3576257

• Allelic Composition: B2m^tm1Unc/B2m^tm1Unc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell number ( J:113083 )

• mucosal-associated invariant T cells (MAIT) that express the canonical mVa19-Ja33 TCR rearrangement and are typically found in the gut lamina propia are virtually absent in these mice

• when wild-type bone marrow is transferred into these mice, MAIT T cells are found in the gut

• when these mice serve as bone marrow donors, MAIT T cells are absent in the gut of irradiated hosts

absent CD8-positive, alpha-beta T cells ( J:64451 )

• deficient in CD4-CD8+ T cells

• CD8+CD4- T cells from the thymus of five week old mice are almost non-existent in comparison to control (0.8% vs. 6.7%), however, total numbers of alpha beta T cells and CD8-CD4+ T cells do not differ significantly from control

decreased level of surface class I molecules ( J:64451 )

• surface expression of class I molecules in cells from lymph nodes, spleen and thymus cannot be detected by flow cytometry

hematopoietic system

abnormal T cell number ( J:113083 )

• mucosal-associated invariant T cells (MAIT) that express the canonical mVa19-Ja33 TCR rearrangement and are typically found in the gut lamina propia are virtually absent in these mice

• when wild-type bone marrow is transferred into these mice, MAIT T cells are found in the gut

• when these mice serve as bone marrow donors, MAIT T cells are absent in the gut of irradiated hosts

absent CD8-positive, alpha-beta T cells ( J:64451 )

• deficient in CD4-CD8+ T cells

• CD8+CD4- T cells from the thymus of five week old mice are almost non-existent in comparison to control (0.8% vs. 6.7%), however, total numbers of alpha beta T cells and CD8-CD4+ T cells do not differ significantly from control