Phenotypes Associated with This Genotype

Genotype
MGI:3577102

• Allelic Composition: Rbbp8^tm1Whl/Rbbp8^tm1Whl
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:97648 )

• homozygotes die at E4 because blastocysts fail to enter S phase

embryo

failure of blastocyst to hatch from the zona pellucida ( J:97648 )

• homozygous blastocysts in culture fail to hatch from the zona pellucida

embryonic growth arrest ( J:97648 )

• homozygous blastocysts in culture show no outgrowth

absent egg cylinders ( J:97648 )

• homozygous embryos fail to form egg cylinders and degenerate in the uterus

cellular

abnormal cell cycle ( J:97648 )

• cells from homozygous blastocysts fail to proliferate and arrest at G1