Analysis Tools
liver/biliary system
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• diffuse hemorrhagic necrosis at death after treatment with combined endotoxin lipopolysaccharide and D-galactosamine or the combination of TNFalpha and Il1b
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nervous system
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• myelinated fibers of femoral quadriceps nerves and cutaneous saphenous nerves appear more densely packed with smaller extracellular spaces
• however, femoral quadriceps nerves and cutaneous saphenous nerves of 13-14 month old mice appear grossly normal, with normal myelinated nerve fiber density and nerve fiber size distribution
• axons of Remak fibers are usually separated by Schwann cell process in wild-type mice, however such separating Schwann cell protrusions are rare in mutants and axons often show direct contacts with neighboring axons indicating ensheathment of Remak bundles
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• smaller internodal, non-compact myelin domains, like Schmidt-Lantermann incisures, are seen
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• thick myelin sheaths, particularly of large and medium-sized caliber axons
• however, degenerative features such as onion bulb cells, denervated Schwann cells, and myelin degeneration are not seen and nerve conduction studies show no differences from wild-type mice
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homeostasis/metabolism
amyloidosis
(
J:104962
)
|
• amyloid beta40 and 42 protein levels are elevated in mutant vs controls at 3-6 and at 11 months of age
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• mice have elevated plasma levels of amyloid beta 42 and 40 relative to controls
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behavior/neurological
| N |
• mice do not show obvious abnormalities in motor performance or coordination
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:69830 | ||
