Phenotypes Associated with This Genotype

Genotype
MGI:3578104

• Allelic Composition: Stat5a^tm1Jni/Stat5a^tm1Jni; Stat5b^tm2Jni/Stat5b^tm2Jni
• Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal myelopoiesis ( J:77412 )

• induction of colony forming cells by Il3 reduced to 57% of controls

• induction of colony forming cells by Il5 reduced to 25% of controls

• induction of colony forming cells by GM-CSF reduced to 47% of controls

increased neutrophil cell number ( J:77412 )

• increased percentage of neutrophiles

decreased leukocyte cell number ( J:77412 )

• due to a decreased percentage of lymphocytes

decreased T cell number ( J:77412 )

• peripheral T cell deficiency

endocrine/exocrine glands

decreased corpora lutea number ( J:77412 )

♀ • few or no large corpora lutea form after ovulation

reproductive system

decreased corpora lutea number ( J:77412 )

♀ • few or no large corpora lutea form after ovulation

female infertility ( J:77412 )

♀

adipose tissue

abnormal fat pad morphology ( J:77412 )

• reduced in size

liver/biliary system

abnormal liver physiology ( J:77412 )

• Major Urinary Protein undetectable in females and dramatically reduced in males

growth/size/body

decreased body weight ( J:77412 )

• weight reduced 20-30% relative to controls in females

• weight reduced 30-40% relative to controls in males

hematopoietic system

abnormal myelopoiesis ( J:77412 )

• induction of colony forming cells by Il3 reduced to 57% of controls

• induction of colony forming cells by Il5 reduced to 25% of controls

• induction of colony forming cells by GM-CSF reduced to 47% of controls

increased neutrophil cell number ( J:77412 )

• increased percentage of neutrophiles

decreased leukocyte cell number ( J:77412 )

• due to a decreased percentage of lymphocytes

decreased T cell number ( J:77412 )

• peripheral T cell deficiency