Phenotypes Associated with This Genotype

Genotype
MGI:3578275

• Allelic Composition: Ahctf1^tm1Taga/Ahctf1^tm1Taga
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:98254 )

• died between E3.5 and E5.5, shortly after implantation

embryo

abnormal inner cell mass apoptosis ( J:98254 )

• inner cell mass cells isolated from homozygous embryos underwent apoptosis during 5-day culture

absent inner cell mass proliferation ( J:98254 )

• inner cell mass cells isolated from homozygous embryos did not proliferate during 5-day culture

abnormal inner cell mass morphology ( J:98254 )

• a distinguishable inner cell mass-like structure was not observed when E3.5 embryos were cultured for 5 days, although the trophectoderm differentiated into giant cells

cellular

abnormal inner cell mass apoptosis ( J:98254 )

• inner cell mass cells isolated from homozygous embryos underwent apoptosis during 5-day culture

absent inner cell mass proliferation ( J:98254 )

• inner cell mass cells isolated from homozygous embryos did not proliferate during 5-day culture