Phenotypes Associated with This Genotype

Genotype
MGI:3578555

• Allelic Composition: Plcg2^Ali5/Plcg2⁺
• Genetic Background: C3HeB/FeJ-Plcg2^Ali5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B-2 B cell number ( J:97930 )

• 50% of heterozygous mutant had an abnormally high ratio of T cells versus mature B cells due to a reduction in the B2 cell number

abnormal B cell physiology ( J:97930 )

• the response in vitro to the mitogens LPS, anti CD40, and IL4 plus anti-IgM was higher for splenic B cells

• anti-DNA antibodies were not detected

chronic inflammation ( J:97930 )

• mice have normal paws at birth but gradually develop swollen and deformed

• male mice were affected earlier at 2 months than female at 8-10 months

osteoarthritis ( J:97930 )

• resulting in severe arthritis of the small joints of the paws and missing phalanges

dermatitis ( J:97930 )

• in the superficial layers of the skin of the paws and ears

skeleton

osteoarthritis ( J:97930 )

• resulting in severe arthritis of the small joints of the paws and missing phalanges

hematopoietic system

decreased B-2 B cell number ( J:97930 )

• 50% of heterozygous mutant had an abnormally high ratio of T cells versus mature B cells due to a reduction in the B2 cell number

abnormal B cell physiology ( J:97930 )

• the response in vitro to the mitogens LPS, anti CD40, and IL4 plus anti-IgM was higher for splenic B cells

• anti-DNA antibodies were not detected

integument

dermatitis ( J:97930 )

• in the superficial layers of the skin of the paws and ears