Phenotypes Associated with This Genotype

Genotype
MGI:3579777

• Allelic Composition: Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:98247 )

• die by E12

cardiovascular system

abnormal blood vessel morphology ( J:98247 )

• thin and well-dilated vessels at E11.5, however did not observe the collapsed or missing anterior cardinal veins displayed by Nr2f2 null mice

• cell layers that separated the artery and vein were greatly reduced at E11.5

abnormal vein morphology ( J:98247 )

• observed budding hematopoietic cell clusters within veins in several regions, including the head vein, the cardinal vein, and the umbilical vein and veins expressed arterial markers Nrp1 (NP-1) and Notch signaling molecules, that were never observed in wildtype veins, suggesting that veins acquire arterial characteristics

hemorrhage ( J:98247 )

• exhibit widespread hemorrhage at E11.5