Phenotypes Associated with This Genotype

Genotype
MGI:3580106

• Allelic Composition: Emx2^tm1Sia/Emx2^tm1Sia; Otx1^tm1Sia/Otx1^tm1Sia
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal pretectal region morphology ( J:98539 )

• development of the pretectum was meager at E18.5 and E12.5

abnormal forebrain morphology ( J:98539 )

• exhibited forebrain defects similar to but milder than the homozygous Emx2 heterozygous Otx2 double mutants

small thalamus ( J:98539 )

• development of prethalamus and thalamus was meager at E18.5 and E12.5

abnormal telencephalon morphology ( J:98539 )

• the telencephalon was smaller, but the choroid plexus developed normally

abnormal hippocampus morphology ( J:98539 )

• the hippocampal field developed poorly at E18.5 and E12.5

abnormal Ammon gyrus morphology ( J:98539 )

• Ammon's horn was deformed

abnormal cerebral cortex morphology ( J:98539 )

• great reduction in the medial pallium