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Phenotypes Associated with This Genotype
Genotype
MGI:3580328
Allelic
Composition		 Cd4tm1Knw/Cd4tm1Knw
Genetic
Background		 B6.129S-Cd4tm1Knw/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Knw mutation (3 available); any Cd4 mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:87828 )
• significantly decreased CD4+ cell population in spleen and thymus as compared to control
increased CD8-positive, alpha-beta T cell number ( J:87828 )
• increased CD8+ cell population in spleen and thymus as compared to control
increased susceptibility to parasitic infection ( J:87828 )
• significantly increased clearance time (24-50 days) after infection by Rickettsiales member (E. chaffeensis)
• granulomatous inflammation in liver is more extensive at 16 days post-infection in contrast to control
• delayed CTL response following second challenge with E. chaffeensis infection

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:87828 )
• significantly decreased CD4+ cell population in spleen and thymus as compared to control
increased CD8-positive, alpha-beta T cell number ( J:87828 )
• increased CD8+ cell population in spleen and thymus as compared to control

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory