Phenotypes Associated with This Genotype

Genotype
MGI:3580890

• Allelic Composition: Atp2b2^dfw-2J/Atp2b2^dfw-2J
• Genetic Background: CByJ.A-Atp2b2^dfw-2J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:38429 )

• no discernible auditory brainstem responses (ABR) to stimuli up to 100 dB

deafness ( J:38429 )

• profoundly deaf

• complete deafness at 3 weeks after birth

absent linear vestibular evoked potential ( J:116914 )

• VESPs are absent at the maximum stimulus intensity used

behavior/neurological

lethargy ( J:38429 )

• becomes increasingly lethargic

abnormal reflex ( J:116914 )

• abnormal drop reflex; mice do not demonstrate expected dorsoflexion and spread out the front paws when quickly lowered from ~20 cm above a table surface, while controls do exhibit this behavior

tremors ( J:38429 )

• a slight body tremor

ataxia ( J:38429 )

• highly unbalanced and uncontrolled movements starting by 12-14 days of age

impaired swimming ( J:116914 )

• mice exhibit poor swimming ability; mice can not maneuver in the water and can not remain at the surface

head bobbing ( J:38429 )

abnormal gait ( J:38429 )

• walk with a hesitant and wobbly gait

reproductive system

infertility ( J:38429 )

• life span is normal, but neither sex breeds