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Phenotypes Associated with This Genotype
Genotype
MGI:3580891
Allelic
Composition		 Atp2b2dfw-2J/Atp2b2+
Genetic
Background		 CByJ.A-Atp2b2dfw-2J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2dfw-2J mutation (1 available); any Atp2b2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:38429 )
• at 4 to 5 weeks of age, significantly elevated sound pressure thresholds
increased susceptibility to age-related hearing loss ( J:38429 )
• hearing loss begins 4 weeks after birth and progresses rapidly to complete deafness by 12 weeks of age
deafness ( J:38429 )
• show age-dependent hearing loss by 12 weeks of age
reduced linear vestibular evoked potential ( J:116914 )
• elevated threshold and reduced amplitudes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory
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