Phenotypes Associated with This Genotype

Genotype
MGI:3581148

• Allelic Composition: Prkdc^scid/Prkdc^scid; Gnrh1^hpg/Gnrh1^hpg
• Genetic Background: STOCK Prkdc^scid Gnrh1^hpg/Bm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased tumor incidence ( J:14443 , J:138840 )

• ovaries grafted from (SWR x SWXJ-9)F1, which are prone to granulosa cell tumor generation, do not form granulosa cell tumors in these hypogonadal immunodeficient hosts (J:14443)

• implanted human prostate adenocarcinoma tissue assessed 3 weeks after transplantation shows two histologic patterns, undifferentiated tumors and tumors that are more differentiated but have few glandular structures, and are smaller and histologically different from the tumors from the same donor transplanted into androgen repleted immunodeficiant hosts (J:138840)

homeostasis/metabolism

decreased circulating testosterone level ( J:138840 )

• no detectable serum testosterone

abnormal circulating protein level ( J:138840 )

• serum lacks detectable prostate-specific antigen

digestive/alimentary system

small salivary gland ( J:138840 )

endocrine/exocrine glands

small salivary gland ( J:138840 )

absent seminal vesicle ( J:138840 )

♂

liver/biliary system

decreased liver weight ( J:138840 )

renal/urinary system

decreased kidney weight ( J:138840 )

reproductive system

absent seminal vesicle ( J:138840 )

♂