Phenotypes Associated with This Genotype

Genotype
MGI:3581169

• Allelic Composition: Sobp^jc/Sobp^jc
• Genetic Background: C57BL/6J-Sobp^jc/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:13506 )

• when suspended by the tail, mice are very active, bobbing up and down and flexing the head and trunk ventrally

hyperactivity ( J:113021 )

• mice, aged 6 weeks and older, spend 1480 seconds/hour in non-stereotypic behavior compared to 576 sec/hour in littermated controls; phenotype is apparent around 3 weeks of age

• hyperactive behavior is significantly different from control strains and wild-derived strains which spent between 325 and 876 seconds/hour in ambulation

• distance covered in a 1 hour period is 409 meters, significantly different from heterozygous littermates and inbred strain controls

circling ( J:13506 , J:116914 )

• circling becomes more erratic with age and is erratic (J:13506)

bidirectional circling ( J:113021 )

• mice perform (mean values) 397 clockwise (CR) and 478 counterclockwise (CCR) rotations per hour compared to 50 CR and 45 CCR in heterozygotes

• circling behavior is similar to other waltzing mutants

hearing/vestibular/ear

abnormal cochlea morphology ( J:113021 )

• aberrant structure forms at the apex of cochlea by E15.5

• at P21, apical turn of cochlea is absent

short scala media ( J:113021 )

• growth of cochlear duct appears to arrest at E13.5; truncation is more pronounced at E15.5

increased or absent threshold for auditory brainstem response ( J:113021 )

• auditory brainstem responses (ABR) measurements show that mutants only respond at high sound pressure levels only

• mice do not show progressive hearing loss; auditory threshold is not age-dependent

• Background Sensitivity: auditory threshold is significantly increased compared to mutants on mixed backgrounds

absent distortion product otoacoustic emissions ( J:113021 )

• mice have no measurable distortion-product otoacoustic emissions (DPOAEs) at 3 primary-tone levels while heterozygotes fall in normal range for all levels

absent linear vestibular evoked potential ( J:116914 )

• VESPs are absent at the maximum stimulus intensity used