Phenotypes Associated with This Genotype

Genotype
MGI:3581210

• Allelic Composition: Mn1^tm1Ecz/Mn1⁺
• Genetic Background: FVB.129-Mn1^tm1Ecz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:98889 )

• 15% died at birth or shortly thereafter

craniofacial

abnormal cranial suture morphology ( J:98889 )

• delayed suture formation between the squamosal and alisphenoid bones at E18.5, with a less dense bone within these sutures and larger foramen ovale and foramen rotundum

basisphenoid bone hypoplasia ( J:98889 )

large cranial foramen ovale ( J:98889 )

• larger foramen ovale

large foramen rotundum ( J:98889 )

• larger foramen rotundum

alisphenoid bone hypoplasia ( J:98889 )

presphenoid bone hypoplasia ( J:98889 )

pterygoid bone hypoplasia ( J:98889 )

temporal bone hypoplasia ( J:98889 )

vomer bone hypoplasia ( J:98889 )

• hypoplastic

palate bone hypoplasia ( J:98889 )

• hypoplastic bone growth within the palatal shelves (both maxillary and palatine processes)

• the mandible and maxilla appear normal

cleft secondary palate ( J:98889 )

• the 15% of heterozygotes that died had cleft secondary palate, but the defects were less severe than in homozygotes

• E15.5 and E16.5 embryos had a closed palate, while E17.5 embryos had a cleft palate

skeleton

abnormal cranial suture morphology ( J:98889 )

• delayed suture formation between the squamosal and alisphenoid bones at E18.5, with a less dense bone within these sutures and larger foramen ovale and foramen rotundum

basisphenoid bone hypoplasia ( J:98889 )

large cranial foramen ovale ( J:98889 )

• larger foramen ovale

large foramen rotundum ( J:98889 )

• larger foramen rotundum

alisphenoid bone hypoplasia ( J:98889 )

presphenoid bone hypoplasia ( J:98889 )

pterygoid bone hypoplasia ( J:98889 )

temporal bone hypoplasia ( J:98889 )

vomer bone hypoplasia ( J:98889 )

• hypoplastic

palate bone hypoplasia ( J:98889 )

• hypoplastic bone growth within the palatal shelves (both maxillary and palatine processes)

• the mandible and maxilla appear normal

neoplasm

neoplasm ( J:98889 )

N • surviving heterozygous mice showed no differences in the number of tumors formed compared to wildtype

digestive/alimentary system

palate bone hypoplasia ( J:98889 )

• hypoplastic bone growth within the palatal shelves (both maxillary and palatine processes)

• the mandible and maxilla appear normal

cleft secondary palate ( J:98889 )

• the 15% of heterozygotes that died had cleft secondary palate, but the defects were less severe than in homozygotes

• E15.5 and E16.5 embryos had a closed palate, while E17.5 embryos had a cleft palate

growth/size/body

palate bone hypoplasia ( J:98889 )

• hypoplastic bone growth within the palatal shelves (both maxillary and palatine processes)

• the mandible and maxilla appear normal

cleft secondary palate ( J:98889 )

• the 15% of heterozygotes that died had cleft secondary palate, but the defects were less severe than in homozygotes

• E15.5 and E16.5 embryos had a closed palate, while E17.5 embryos had a cleft palate