Analysis Tools
mortality/aging
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• females displaying vaginal atresia accumulate fluid in the uterus and die between 4 and 6 months of age
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• similar to Rb1tm1Tyj heterozygotes, any surviving mutant mice eventually die of pituitary tumors after 12 months
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• at 1 week of age, mutant pups are obtained at a significantly lower frequency (19%) than expected (25%)
• most mutants die within the first 3 weeks of age, with only about 25% surviving beyond 3 weeks
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endocrine/exocrine glands
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• similar to Rb1tm1Tyj heterozygotes, all surviving mutant mice develop large pituitary adenocarcinomas of the intermediate lobe
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growth/size/body
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• mutant pups become runted several days after birth
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• beginning at ~1 week, mutant pups appear severely growth retarded, averaging 50% of the weight of control littermates
• mutants surviving beyond 3 weeks of age gain weight slowly, averaging 70-90% of normal weight at 3 months
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• although mutant pups are of approximately uniform size at birth, a number of pups display severe growth retardation, with weight differences persisting for several weeks
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• females displaying vaginal atresia have a distended abdomen as a result of fluid accumulation in the uterus
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neoplasm
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• similar to Rb1tm1Tyj heterozygotes, all surviving mutant mice develop large pituitary adenocarcinomas of the intermediate lobe
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reproductive system
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• females displaying vaginal atresia have a distended perineum as a result of fluid accumulation in the uterus
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• ~75% of mutant females display vaginal atresia whereas the majority of mutant males surviving beyond 3 weeks of age are fertile and appear normal up to 12 months
• in affected females, the vaginal opening is absent; however, the rest of the reproductive tract appears unaffected
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vision/eye
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• at 4-6 months, all mutant mice display retinal dysplasia; both eyes are affected in 11 out of 12 mutants
• typically, each eye contains 5-7 individual lesions composed of small white bodies (usually in clusters), indicating retinal pathology
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• as early as 4 days after birth, mutant newborns exhibit mild, yet significant, disruptions of the retinal photoreceptor layer
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nervous system
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• similar to Rb1tm1Tyj heterozygotes, all surviving mutant mice develop large pituitary adenocarcinomas of the intermediate lobe
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• as early as 4 days after birth, mutant newborns exhibit mild, yet significant, disruptions of the retinal photoreceptor layer
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digestive/alimentary system
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• females displaying vaginal atresia have a distended perineum as a result of fluid accumulation in the uterus
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