Phenotypes Associated with This Genotype

Genotype
MGI:3582618

• Allelic Composition: Rb1^tm1Tyj/Rb1⁺; Rbl1^tm1Tyj/Rbl1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:34058 )

• similar to Rb1^tm1Tyj heterozygotes, mice heterozygous for both Rb1^tm1Tyj and Rbl1^tm1Tyj die from tumors in the intermediate lobe of the pituitary gland at ~12 months of age

neoplasm

increased pituitary gland tumor incidence ( J:34058 )

• double heterozygotes develop large pituitary tumors of the intermediate lobe that are comparable to those arising in single Rb1^tm1Tyj heterozygotes with respect to both incidence and size

• such pituitary tumors are shown to arise from cells in which the wild-type allele of Rb1 is absent, whereas the wild-type allele of Rbl1 is retained

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:34058 )

• double heterozygotes develop large pituitary tumors of the intermediate lobe that are comparable to those arising in single Rb1^tm1Tyj heterozygotes with respect to both incidence and size

• such pituitary tumors are shown to arise from cells in which the wild-type allele of Rb1 is absent, whereas the wild-type allele of Rbl1 is retained

nervous system

increased pituitary gland tumor incidence ( J:34058 )

• double heterozygotes develop large pituitary tumors of the intermediate lobe that are comparable to those arising in single Rb1^tm1Tyj heterozygotes with respect to both incidence and size

• such pituitary tumors are shown to arise from cells in which the wild-type allele of Rb1 is absent, whereas the wild-type allele of Rbl1 is retained