Analysis Tools
homeostasis/metabolism
 |
• at 6-10 weeks, male hemizygotes show an impaired tolerance that is statistically significant at the 60, 90, and 120 min time points of the oral glucose tolerance test
|
reproductive system
|
|
• male hemizygotes exhibit reduced ability to produce live offspring when mated with homozygous mutant females
|
|
|
• pairs of mutant mice produce an average of 2.0 0.5 litters per pair (range 0-3), whereas wild-type mice produce an average of 3.1 0.1 litters per pair (range 3-4)
• ~50% of mutant litters die within a few days of birth relative to only 8% of wild-type litters
• the average sizes of surviving litters are almost the same for mutant and wild-type mice
|
