Phenotypes Associated with This Genotype

Genotype
MGI:3583265

• Allelic Composition: Irs1^tm1Jos/Irs1^tm1Jos; Irs4^tm1Lhd/Y
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

postnatal growth retardation ( J:80976 )

♂ • these mutant males display no significant differences from Irs1^tm1Jos homozygous males with respect to growth or organ size

homeostasis/metabolism

increased circulating insulin level ( J:80976 )

♂ • at 10-17-weeks, these mutant males show no significant differences from Irs1^tm1Jos homozygous males with respect to fed and fasted plasma insulin levels

impaired glucose tolerance ( J:80976 )

♂ • at 9-12 weeks, double mutant males and Irs1^tm1Jos homozygous males show no significant differences in fed and fasted blood glucose levels; both groups display a comparable (mild) reponse when subjected to glucose tolerance tests

insulin resistance ( J:80976 )

♂ • at 9-12 weeks, double mutant males and Irs1^tm1Jos homozygous males show a comparable (mild) reponse when subjected to insulin tolerance tests