Phenotypes Associated with This Genotype

Genotype
MGI:3583696

• Allelic Composition: Fgl2^tm1Pam/Fgl2^tm1Pam
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:99453 )

• esistant to murine hepatitis virus type 3 (MHV-3) induced death

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:99453 )

• partial lethality between E8.5 and E10.5, with 40% lost when checked at weaning

immune system

decreased susceptibility to Coronaviridae infection ( J:99453 )

• resistant to murine hepatitis virus type 3 (MHV-3) induced liver necrosis

decreased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:99453 )

• esistant to murine hepatitis virus type 3 (MHV-3) induced death

homeostasis/metabolism

abnormal blood coagulation ( J:99453 )

• MHV-3 infection failed to induce procoagulant activity in thioglycollate-elicited peritoneal macarophages

cardiovascular system

hemorrhage ( J:99453 )

• many E8.5 embryos show moderate to severe hemorrhage at implantation sites, with extravasation of maternal erythrocytes between the mural trophectoderm and Reichert's membrane