Analysis Tools
mortality/aging
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• resistant to murine hepatitis virus type 3 (MHV-3) induced death
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• partial lethality
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growth/size/body
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• mice are smaller at 7 months of age, but not at 6- to 8-weeks of age
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weight loss
(
J:130895
)
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• mice weigh less at 7 months of age, but not at 6- to 8-weeks of age, indicating that mice lose weight with age
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renal/urinary system
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• presence of hemorrhage within the kidney
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• progressive increase in the level of albumin in the urine
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• by 3 months of age, mice show focal segmental mesangial thickening and a mild increase in cellularity of glomeruli
• by 6 months of age, glomerular changes are severe with widespread generalized increase in cellularity, mesangial thickening, and decrease in vascularity
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• at 6 months of age, 25% of mice develop severe glomerulonephritis, with characteristically small and yellow kidneys, and show a heavy interstitial inflammatory cell infiltration comprised predominately of lymphocytes
• kidneys show extensive infiltration of mononuclear cells and interstitial fibrosis, collapse of many renal tubules that are surrounded with fibrin and mesangial expansion in the glomerulus
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• by 3 months of age, mice show focal segmental mesangial thickening and by 6 months of age, mesangial thickening is more severe
• IgG, IgM, and IgA are seen in glomerular mesangium and the infiltrating cells and C3 deposits are seen at 1, 3, and 6 months of age
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• kidneys show fibrosis at 6 months of age
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small kidney
(
J:130895
)
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• kidney size is smaller in 25% of mice by 7 months of age
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• kidney weight is smaller in 25% of mice at 7 months of age
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immune system
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• mice show a 30% increase in the proportion and absolute numbers of dendritic cells (CD11c+MHCII+) in the spleen, while the proportions of macrophages are normal
• an increase in the number of dendritic cells is seen from in vitro bone marrow cultures
• iall plasmacytoid and myeloid dendritic cells subsets in the spleen and bone marrow are increased
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• increase in the percentage of Treg cells in all lymphoid tissues; the increase corresponds to a higher absolute number of Treg cells in all lymphoid organs
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• mice show an increase in numbers of antibody-producing B cells in response to T-independent antigens, LPS, and NP-Ficoll, but normal response to T-dependent antigen NP-CGG
• however, the amount of antibody produced per cell is similar to wild-type mice
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• IgA is seen in glomeruli
• however, levels of IgG and IgM autoantibodies against dsDNA, ssDNA, or chromatin in aged mice is normal
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• IgG is seen in glomeruli
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• IgM is seen in glomeruli
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• effector T cells are polarized toward a Th1 response
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• T cells have increased proliferation in response to ConA and in a one-way mixed lymphocyte reaction
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• CD4+CD25- T cells cultured in the presence of irradiated splenocytes are less efficient in suppressing CD4+ T cell proliferation compared to wild-type T cell, indicating that Treg suppressive activity is impaired
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• older mice show decreased number of Peyers Patch follicles
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• 25% fewer Peyers Patches in the small intestine of young mice
• older mice show decreased number of intestinal Peyers Patches and follicles
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• increase in reactivity of dendritic cells
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• apoptosis of LPS-stimulated dendritic cells in culture is decreased and delayed
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• at 6 months of age, 25% of mice develop severe glomerulonephritis, with characteristically small and yellow kidneys, and show a heavy interstitial inflammatory cell infiltration comprised predominately of lymphocytes
• kidneys show extensive infiltration of mononuclear cells and interstitial fibrosis, collapse of many renal tubules that are surrounded with fibrin and mesangial expansion in the glomerulus
|
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• resistant to murine hepatitis virus type 3 (MHV-3) induced liver necrosis
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• resistant to murine hepatitis virus type 3 (MHV-3) induced death
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cellular
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• apoptosis of LPS-stimulated dendritic cells in culture is decreased and delayed
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• T cells have increased proliferation in response to ConA and in a one-way mixed lymphocyte reaction
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hematopoietic system
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• mice show a 30% increase in the proportion and absolute numbers of dendritic cells (CD11c+MHCII+) in the spleen, while the proportions of macrophages are normal
• an increase in the number of dendritic cells is seen from in vitro bone marrow cultures
• iall plasmacytoid and myeloid dendritic cells subsets in the spleen and bone marrow are increased
|
|
• increase in the percentage of Treg cells in all lymphoid tissues; the increase corresponds to a higher absolute number of Treg cells in all lymphoid organs
|
|
• mice show an increase in numbers of antibody-producing B cells in response to T-independent antigens, LPS, and NP-Ficoll, but normal response to T-dependent antigen NP-CGG
• however, the amount of antibody produced per cell is similar to wild-type mice
|
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• IgA is seen in glomeruli
• however, levels of IgG and IgM autoantibodies against dsDNA, ssDNA, or chromatin in aged mice is normal
|
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• IgG is seen in glomeruli
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• IgM is seen in glomeruli
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• effector T cells are polarized toward a Th1 response
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• T cells have increased proliferation in response to ConA and in a one-way mixed lymphocyte reaction
|
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• CD4+CD25- T cells cultured in the presence of irradiated splenocytes are less efficient in suppressing CD4+ T cell proliferation compared to wild-type T cell, indicating that Treg suppressive activity is impaired
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homeostasis/metabolism
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• increase in serum creatinine with age
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• progressive increase in the level of albumin in the urine
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cardiovascular system
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• presence of hemorrhage within the kidney
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autoimmune glomerulonephritis | DOID:0040094 | J:130895 | ||
