Phenotypes Associated with This Genotype

Genotype
MGI:3587806

• Allelic Composition: Bmp5^se/Bmp5^se
• Genetic Background: P/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal outer ear morphology ( J:15478 )

• scapha, the rings that surround the external auditory meatus, the crus helicis and most of the basal part of the cartilage are all reduced

abnormal outer ear cartilage morphology ( J:15478 )

• cartilage is entirely absent in the scapha and reduced in size in all other parts of the ear

small ears ( J:15478 )

• Background Sensitivity: ears are smaller than in the NB background

• ear is shrunken and ruffled due to cartilage defects

skeleton

abnormal outer ear cartilage morphology ( J:15478 )

• cartilage is entirely absent in the scapha and reduced in size in all other parts of the ear

abnormal xiphoid process morphology ( J:15478 )

• Background Sensitivity: xiphisternum is either very reduced or completely absent in the P/J background and is bifurcated in the NB background

abnormal cartilage development ( J:15478 )

• the basal part of the ear cartilage does not develop as well as in controls and is smaller and thinner by time of birth

• condenstation of mesenchyme leading to cartilage formation is defective in the xiphoid region of the sternal bands, in the annular cartilages of the meatus, and in the scapha

craniofacial

abnormal outer ear morphology ( J:15478 )

• scapha, the rings that surround the external auditory meatus, the crus helicis and most of the basal part of the cartilage are all reduced

abnormal outer ear cartilage morphology ( J:15478 )

• cartilage is entirely absent in the scapha and reduced in size in all other parts of the ear

small ears ( J:15478 )

• Background Sensitivity: ears are smaller than in the NB background

• ear is shrunken and ruffled due to cartilage defects

growth/size/body

abnormal outer ear morphology ( J:15478 )

• scapha, the rings that surround the external auditory meatus, the crus helicis and most of the basal part of the cartilage are all reduced

abnormal outer ear cartilage morphology ( J:15478 )

• cartilage is entirely absent in the scapha and reduced in size in all other parts of the ear

small ears ( J:15478 )

• Background Sensitivity: ears are smaller than in the NB background

• ear is shrunken and ruffled due to cartilage defects