Phenotypes Associated with This Genotype

Genotype
MGI:3588434

• Allelic Composition: Med1^tm1Rgr/Med1⁺
• Genetic Background: either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:61840 )

• after weaning, heterozygotes are significantly smaller than wild-type mice

decreased body height ( J:61840 )

• heterozygotes are shorter than wild-type mice; however, no other morphological abnormalities are observed

postnatal growth retardation ( J:61840 )

• heterozygotes display significant growth retardation after weaning

• no significant differences in weight are observed throughout embryogenesis and at birth

homeostasis/metabolism

decreased circulating thyroxine level ( J:61840 )

• at 12 weeks, the serum levels of free T4 are significantly reduced in heterozygous F1 males relative to wild-type levels

decreased circulating triiodothyronine level ( J:61840 )

• at 12 weeks, the serum levels of free T3 are significantly reduced in heterozygous F1 males relative to wild-type levels

decreased thyroid-stimulating hormone level ( J:61840 )

• at 12 weeks, male heterozygotes show a significant decrease in pituitary TSH-beta production without significant changes in TSH-alpha or growth hormone (GH) production

abnormal metabolism ( J:61840 )

• heterozygotes exhibit widely impaired transcription and post-transcriptional regulation in certain organs

endocrine/exocrine glands

decreased activity of thyroid gland ( J:61840 )

• heterozygotes exhibit pituitary hypothyroidism due to a reduction in pituitary TSH-beta mRNA levels; no changes in TRH mRNA levels are observed