Phenotypes Associated with This Genotype

Genotype
MGI:3588776

• Allelic Composition: Tlr4^tm1Aki/Tlr4^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired neutrophil chemotaxis ( J:98224 )

• decreased neutrophil chemotaxis

enlarged mesenteric lymph nodes ( J:98224 )

• weights of mesenteric lymph nodes 2X controls

abnormal acute inflammation ( J:98224 )

• colitis induced by dextran sodium sulfate involves less inflammatory cell infiltration with fewer neurophils in the lamina propria and submucosa

• epithelial damage normal but decreased epithelial proliferation

• earlier and more severe rectal bleeding

increased susceptibility to bacterial infection ( J:98224 )

• increased numbers of gram (-) bacteria in mesenteric lymph node

hematopoietic system

impaired neutrophil chemotaxis ( J:98224 )

• decreased neutrophil chemotaxis

decreased hemoglobin content ( J:98224 )

• reduced hemoglobin in mice with colitis induced by dextran sodium sulfate

cellular

impaired neutrophil chemotaxis ( J:98224 )

• decreased neutrophil chemotaxis