Phenotypes Associated with This Genotype

Genotype
MGI:3589255

• Allelic Composition: Pak3^tm1Zpj/Pak3^tm1Zpj
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

reduced long-term potentiation ( J:99811 )

♀ • selectively impaired in late-phase hippocampal long-term potentiation

♀ • no deficits in either neuronal structures or the actin cytoskeleton were found

behavior/neurological

abnormal conditioned taste aversion behavior ( J:99811 )

♀ • accelerated extinction of the hippocampus independent taste aversion associative learning task

♀ • hippocampus-dependent spatial memory was not affected