Phenotypes Associated with This Genotype

Genotype
MGI:3589447

• Allelic Composition: Ndst1^tm1.1Grob/Ndst1⁺; Shh^tm1Chg/Shh⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

mandible hypoplasia ( J:100425 )

• at E15.5, 4 of 8 mutants display hyploplastic lower jaws

frontonasal prominence hypoplasia ( J:100425 )

• at E15.5, 4 of 8 mutants display hypoplastic frontonasal or maxillary processes

abnormal maxillary prominence morphology ( J:100425 )

• at E15.5, 4 of 8 mutants display hypoplastic frontonasal or maxillary processes

absent tongue ( J:100425 )

• at E15.5, 4 of 8 mutants lack a tongue

absent olfactory epithelium ( J:100425 )

• at E15.5, 4 of 8 mutants lack olfactory epithelium

small snout ( J:100425 )

• surviving mutants generally have a smaller snout

vision/eye

aphakia ( J:100425 )

• at E15.5, 4 of 8 mutants display absent or hypoplastic eye lenses

abnormal eye development ( J:100425 )

• at E15.5, 4 of 8 mutants display severe eye developmental defects

microphthalmia ( J:100425 )

• surviving mutants generally have smaller eyes

digestive/alimentary system

absent tongue ( J:100425 )

• at E15.5, 4 of 8 mutants lack a tongue

taste/olfaction

absent olfactory epithelium ( J:100425 )

• at E15.5, 4 of 8 mutants lack olfactory epithelium

skeleton

mandible hypoplasia ( J:100425 )

• at E15.5, 4 of 8 mutants display hyploplastic lower jaws

respiratory system

absent olfactory epithelium ( J:100425 )

• at E15.5, 4 of 8 mutants lack olfactory epithelium

growth/size/body

absent tongue ( J:100425 )

• at E15.5, 4 of 8 mutants lack a tongue

absent olfactory epithelium ( J:100425 )

• at E15.5, 4 of 8 mutants lack olfactory epithelium

small snout ( J:100425 )

• surviving mutants generally have a smaller snout