Phenotypes for Ndst1 Shh MGI:3589448 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ndst1^tm1.1Grob/Ndst1^tm1.1Grob Shh^tm1Chg/Shh⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst1^tm1.1Grob mutation (0 available); any Ndst1 mutation (47 available)
Shh^tm1Chg mutation (2 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:100425 )

• 3-times fewer than expected mutants are produced

craniofacial

frontonasal prominence hypoplasia ( J:100425 )

• 4 of 5 mutants display severely hypoplastic frontonasal prominences similar to defects seen in severely affected Ndst1^tm1.1Grob single homozygotes

abnormal maxillary prominence morphology ( J:100425 )

• 4 of 5 mutants display severely hypoplastic maxillary prominences similar to defects seen in severely affected Ndst1^tm1.1Grob single homozygotes

nervous system

abnormal midbrain morphology ( J:100425 )

• all mutants display collapse of the midbrain

abnormal forebrain morphology ( J:100425 )

• all mutants display collapse of the forebrain

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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