Phenotypes for B2m Foxp3 Otc MGI:3590073 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	B2m^tm1Jae/B2m^tm1Jae Foxp3^sf Otc^spf/Y
Genetic Background	involves: 129/Rl * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2m^tm1Jae mutation (8 available); any B2m mutation (121 available)
Foxp3^sf mutation (5 available); any Foxp3 mutation (58 available)
Otc^spf mutation (9 available); any Otc mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:20865 )

enlarged spleen ( J:20865 )

immune system

increased plasma cell number ( J:20865 )

• plasma cell hyperplasia within the spleen and lymph nodes

increased CD4-positive, alpha-beta T cell number ( J:20865 )

• greater percentage of CD45RB^dullCD4+ T cells than in homozygous B2m mice

increased immunoglobulin level ( J:20865 )

increased IgG level ( J:20865 )

increased IgM level ( J:20865 )

abnormal interleukin level ( J:20865 )

• increased amounts of IL-4, IL-6, and IL-10 and decreased amounts of IL-2 in Con A stimulated day 16 splenocytes

abnormal tumor necrosis factor level ( J:20865 )

• decreased amount of TNF-alpha in Con A stimulated day 16 splenocytes

abnormal immune system organ morphology ( J:20865 )

enlarged spleen ( J:20865 )

abnormal lymph node morphology ( J:20865 )

• complete disruption of normal architecture, with abundant lymphoblasts and reticular cell hyperplasia

enlarged lymph nodes ( J:20865 )

dermatitis ( J:20865 )

• exfoliative dermatitis

hematopoietic system

enlarged spleen ( J:20865 )

anemia ( J:20865 )

decreased hematocrit ( J:20865 )

increased plasma cell number ( J:20865 )

• plasma cell hyperplasia within the spleen and lymph nodes

increased CD4-positive, alpha-beta T cell number ( J:20865 )

• greater percentage of CD45RB^dullCD4+ T cells than in homozygous B2m mice

increased immunoglobulin level ( J:20865 )

increased IgG level ( J:20865 )

increased IgM level ( J:20865 )

homeostasis/metabolism

abnormal interleukin level ( J:20865 )

• increased amounts of IL-4, IL-6, and IL-10 and decreased amounts of IL-2 in Con A stimulated day 16 splenocytes

abnormal tumor necrosis factor level ( J:20865 )

• decreased amount of TNF-alpha in Con A stimulated day 16 splenocytes

integument

dermatitis ( J:20865 )

• exfoliative dermatitis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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