Phenotypes for Pax3 Pax7 MGI:3603041 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pax3^tm1Buck/Pax3^tm1Buck Pax7^tm2Pgr/Pax7^tm2Pgr
Genetic Background	either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3^tm1Buck mutation (1 available); any Pax3 mutation (50 available)
Pax7^tm2Pgr mutation (2 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:99365 )

• double homozygotes die at mid-gestation

muscle

abnormal myotome development ( J:99365 )

• at E11.5 there is a significant decrease in the differentiated muscle cells and by E13.5 only a few muscle fibers are present

• increased apoptosis is seen at E11.5 unlike in Pax3 single homozygotes

• progenitor cells at later embryonic and fetal stages are not specified as skeletal muscle

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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