Phenotypes Associated with This Genotype

Genotype
MGI:3606860

• Allelic Composition: Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn; Tg(KRT14-cre/ERT2)1Ipc/?
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal digit morphology ( J:101729 )

• if tamoxifen given to mothers between E9.5 and 13.5

• if induction with tamoxifen occurred between E12.5 and 16.5 then all limbs are normal

abnormal hindlimb morphology ( J:101729 )

• malformed in contrast to forelimbs which are normal if tamoxifen given to mothers between E9.5 and 13.5

• if induction with tamoxifen occurred between E12.5 and 16.5 then all limbs are normal

homeostasis/metabolism

impaired skin barrier function ( J:101729 )

• regardless of when tamoxifen induction occurred

integument

impaired skin barrier function ( J:101729 )

• regardless of when tamoxifen induction occurred

abnormal skin morphology ( J:101729 )

• regardless of when tamoxifen induction occurred

abnormal epidermis stratum corneum morphology ( J:101729 )

• 5 fold fewer corneodesmosomes