Phenotypes Associated with This Genotype

Genotype
MGI:3608974

• Allelic Composition: Onecut2^tm1Flem/Onecut2^tm1Flem
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

abnormal bile duct development ( J:100352 )

• biliary cells persist in ductal plate configuration or delineate enlarged biliary structures instead of giving rise to the bile ducts

abnormal liver morphology ( J:100352 )

• premature dilations are seen within the ductal plates of embryonic livers

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:121610 )

N • at E10.5, dorsal and ventral pancreatic buds appear normal; similar results show no difference compared to controls at E14.5

N • at E14.5 and E18.5, expression of Neurog3, insulin, and glucagons is comparable to wild-type embryos; endocrine differentiation is normal

N • no enteroendocrine defect is observed; pyloric region is normal, Brunner's glands are present in duodenum, and crypt/villus architecture in small intestine is not altered

N • enteroendocrine cells differentiate normally

abnormal bile duct development ( J:100352 )

• biliary cells persist in ductal plate configuration or delineate enlarged biliary structures instead of giving rise to the bile ducts