Phenotypes Associated with This Genotype

Genotype
MGI:3608976

• Allelic Composition: Onecut1^tm1Flem/Onecut1^tm1Flem; Onecut2^tm1Flem/Onecut2^tm1Flem
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

abnormal hepatoblast differentiation ( J:100352 )

• hepatoblast differentiation is perturbed such that they differentiate into hybrid cells that display characteristics of both hepatocytes and biliary cells

abnormal hepatic cord morphology ( J:100352 )

• cord-like organization of the epithelial cells in the parenchyma is severely perturbed in E15.5 embryos with epithelial cells forming clusters surrounded by hematopoietic cells

endocrine/exocrine glands

abnormal pancreas development ( J:121610 )

• at E13.5, dorsal pancreas is smaller than in Onecut1-deficient embryos; no ventral bud is observed, instead consisting of two small cell clusters on the duodenum

• endocrine differentiation is more affected than in Onecut1-null embryos; pancreas sections almost completely lack Neurog3-expressing cells (~0.5 cells/section)

• insulin- and glucagon-expressing cells are almost absent

• endocrine differentiation initiates normally at E9.5 and progresses comparably to wild-type at E10.5, but becomes defective by E12.5