Phenotypes Associated with This Genotype

Genotype
MGI:3608993

• Allelic Composition: Smad4^tm2.1Cxd/Smad4^tm2.1Cxd; Tg(Nes-cre)1Atp/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:86155 )

• when the Nes-Cre transgene is paternally derived, mutant embryos die at early post-implantation stages, however if the Nes-Cre transgene is maternally derived, mutants survive to adulthood

nervous system

decreased Purkinje cell number ( J:86155 )

• number of parvalbumin-containing Purkinje cells is only 43% of that in controls, however hippocampus and synaptic plasticity are normal

abnormal cerebellar molecular layer ( J:86155 )

• number of parvalbumin-positive interneurons in the molecular layer is decreased by 34.4%

behavior/neurological

increased vertical activity ( J:86155 )

• exhibit substantially higher vertical activity, however no differences in the balance bar task, rotarod assay, or horizontal activity