Phenotypes Associated with This Genotype

Genotype
MGI:3611474

• Allelic Composition: Kcnq1^vtg-3J/Kcnq1^vtg-3J
• Genetic Background: C57BL/6J-Kcnq1^vtg-3J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:87349 )

• from approximately 3.7 weeks of age, mutant mice exhibit a noticeable body tremor

impaired balance ( J:87349 )

• mutant mice sometimes lean slightly to the side

head tossing ( J:87349 )

abnormal gait ( J:87349 )

• homozygous mice occasionally lift both hind limbs simultaneously

retropulsion ( J:87349 )

• homozygous mutant mice occasionally exhibit backward locomotion

circling ( J:87349 )

hearing/vestibular/ear

abnormal cochlea morphology ( J:87349 )

• examination of sections of the ears reveals severe malformation of the cochlea, with collapse of the cochlear ducts

abnormal inner ear vestibule morphology ( J:87349 )

• examination of sections of the ears reveals severe malformation of the vestibular region, with collapse of the the endolymphatic portion of the vestibular system

abnormal otolith morphology ( J:87349 )

• examination of the whole ear revealed abnormal otoconia