Phenotypes Associated with This Genotype

Genotype
MGI:3611476

• Allelic Composition: Lhfpl5^hscy-2J/Lhfpl5^hscy-2J
• Genetic Background: C57BL/6J-Lhfpl5^hscy-2J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:87349 , J:125709 )

• auditory-evoked brainstem response (ABR) testing of 5-6 week old mutant mice showed them to be deaf at every frequency tested (click, 8, 16 and 32kHz) (J:87349)

• auditory stimuli up to 100 dB SPL fail to elicit ABRs at 34 days of age (J:125709)

deafness ( J:87349 )

behavior/neurological

impaired balance ( J:87349 )

• at weaning, mutant mice exhibit sideways leaning

head shaking ( J:125709 )

• slight head shake by approximately 3 weeks of age

head tilt ( J:87349 )

circling ( J:87349 )

bidirectional circling ( J:125709 )