Phenotypes Associated with This Genotype

Genotype
MGI:3614443

hm1

• Allelic Composition: Ccr1^tm1Gao/Ccr1^tm1Gao
• Genetic Background: B6.129S4-Ccr1^tm1Gao

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal response to cardiac infarction ( J:104744 )

• recruitment of neutrophils during reperfusion is reduced, with reduced leukocyte adhesion to the inner vessel wall of postcapillary venules and reduced number of transmigrated leukocytes

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:162707 )

• 40% of rMA15 SARS-CoV-infected mice succumb to infection by 7 days post infection

immune system

abnormal cellular extravasation ( J:104744 )

• at 120 min of reperfusion, show a 53.1% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type

abnormal leukocyte adhesion ( J:104744 )

• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to the number of rolling leukocytes

bronchiolitis ( J:162707 )

• rMA15 SARS-CoV-infected mice exhibit more severe denuding bronchiolitis than wild-type mice, with an accumulation of cohesive apoptotic debris within the airway

increased susceptibility to Coronaviridae infection ( J:162707 )

• mice show increased susceptibility to infection with a recombinant mouse-adapted SARS-CoV, rMA15 , developing more severe and prolonged disease compared to wild-type mice, showing more prominent airway epithelial cell apoptosis, severe denuding bronchiolitis and perivenular/periarterial cuffing

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:162707 )

• 40% of rMA15 SARS-CoV-infected mice succumb to infection by 7 days post infection

homeostasis/metabolism

abnormal response to cardiac infarction ( J:104744 )

• recruitment of neutrophils during reperfusion is reduced, with reduced leukocyte adhesion to the inner vessel wall of postcapillary venules and reduced number of transmigrated leukocytes

cellular

abnormal cellular extravasation ( J:104744 )

• at 120 min of reperfusion, show a 53.1% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type

abnormal leukocyte adhesion ( J:104744 )

• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to the number of rolling leukocytes

hematopoietic system

abnormal cellular extravasation ( J:104744 )

• at 120 min of reperfusion, show a 53.1% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type

abnormal leukocyte adhesion ( J:104744 )

• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to the number of rolling leukocytes

respiratory system

bronchiolitis ( J:162707 )

• rMA15 SARS-CoV-infected mice exhibit more severe denuding bronchiolitis than wild-type mice, with an accumulation of cohesive apoptotic debris within the airway

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Coronavirus infectious disease		DOID:0080599		J:162707