Analysis Tools
immune system
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• by 12-24 weeks of age, CD8+ numbers begin to rise in transgenic mice such that eventually cells from the spleen and lymph nodes (LN) of transgenic mice contain up to 10-fold the numbers of CD8+ T cells seen in splenocytes and LN cells of control mice, whereas absolute numbers of splenic and LN CD4+ T cells and of B cells in transgenic mice are similar to or lower than in control mice
• the CD4+/CD8+ T cell ratio of transgenic mice between 12 and 24 weeks of age becomes severely skewed in favor of CD8+ T cells due to the expansion of CD8+ cells
• a significantly higher proportion of lymph node T cells is cycling in transgenic than in littermate control mice
• the proportion of peripheral CD8+ T cells that are acively cycling in transgenic mice reaches the level (5-8%) seen in thymi of both transgenic and wild-type mice
• over time, the expanded CD8+ T cell population in transgenic mice progresses from polyclonal to oligoclonal - representing several clonal lineages - to, by 6-12 months of age, monoclonal or biclonal, based on the T cell beta variable region (TCR-Vb) repertoire of the population
• moderate infiltration of the heart, liver and lungs with small lymphocytes occurs in transgenic mice; however, inflammation is minimal
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• spleens of transgenic mice become enlarged, with marked infiltration by small lymphocytes
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• lymph nodes of transgenic mice become enlarged, with marked infiltration by small lymphocytes
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hematopoietic system
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• by 12-24 weeks of age, CD8+ numbers begin to rise in transgenic mice such that eventually cells from the spleen and lymph nodes (LN) of transgenic mice contain up to 10-fold the numbers of CD8+ T cells seen in splenocytes and LN cells of control mice, whereas absolute numbers of splenic and LN CD4+ T cells and of B cells in transgenic mice are similar to or lower than in control mice
• the CD4+/CD8+ T cell ratio of transgenic mice between 12 and 24 weeks of age becomes severely skewed in favor of CD8+ T cells due to the expansion of CD8+ cells
• a significantly higher proportion of lymph node T cells is cycling in transgenic than in littermate control mice
• the proportion of peripheral CD8+ T cells that are acively cycling in transgenic mice reaches the level (5-8%) seen in thymi of both transgenic and wild-type mice
• over time, the expanded CD8+ T cell population in transgenic mice progresses from polyclonal to oligoclonal - representing several clonal lineages - to, by 6-12 months of age, monoclonal or biclonal, based on the T cell beta variable region (TCR-Vb) repertoire of the population
• moderate infiltration of the heart, liver and lungs with small lymphocytes occurs in transgenic mice; however, inflammation is minimal
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• spleens of transgenic mice become enlarged, with marked infiltration by small lymphocytes
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cellular
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• by 12-24 weeks of age, CD8+ numbers begin to rise in transgenic mice such that eventually cells from the spleen and lymph nodes (LN) of transgenic mice contain up to 10-fold the numbers of CD8+ T cells seen in splenocytes and LN cells of control mice, whereas absolute numbers of splenic and LN CD4+ T cells and of B cells in transgenic mice are similar to or lower than in control mice
• the CD4+/CD8+ T cell ratio of transgenic mice between 12 and 24 weeks of age becomes severely skewed in favor of CD8+ T cells due to the expansion of CD8+ cells
• a significantly higher proportion of lymph node T cells is cycling in transgenic than in littermate control mice
• the proportion of peripheral CD8+ T cells that are acively cycling in transgenic mice reaches the level (5-8%) seen in thymi of both transgenic and wild-type mice
• over time, the expanded CD8+ T cell population in transgenic mice progresses from polyclonal to oligoclonal - representing several clonal lineages - to, by 6-12 months of age, monoclonal or biclonal, based on the T cell beta variable region (TCR-Vb) repertoire of the population
• moderate infiltration of the heart, liver and lungs with small lymphocytes occurs in transgenic mice; however, inflammation is minimal
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growth/size/body
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• spleens of transgenic mice become enlarged, with marked infiltration by small lymphocytes
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