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Phenotypes Associated with This Genotype
Genotype
MGI:3616175
Allelic
Composition		 Ptafrtm1Eit/Ptafrtm1Eit
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptafrtm1Eit mutation (0 available); any Ptafr mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood-brain barrier function ( J:104293 )
• null mutants infected with bacteria show a significantly increased resistance to bacterial translocation
abnormal vascular endothelial cell physiology ( J:104293 )
• bacterial translocation into the blood and from blood into cerebrospinal fluid is delayed

nervous system
abnormal blood-brain barrier function ( J:104293 )
• null mutants infected with bacteria show a significantly increased resistance to bacterial translocation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory