Phenotypes Associated with This Genotype

Genotype
MGI:3617226

• Allelic Composition: Mylk2^tm1Jtst/Mylk2^tm1Jtst
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

impaired skeletal muscle contractility ( J:104384 )

• in extensor digitorum longus muscle at 10 s after a tetanic stimulation (150 Hz for 2 s) no increase in twitch tension is seen, unlike in wild-type mice where a 75% increase is seen

• in extensor digitorum longus muscle following repetitive stimulation at a constant low frequency the initial transient decrease is present but during the recovery phase the maximum tension increase is only 30% compared to 55% in wild-type

• in both cases phosphorylation of regulatory light chain myosin is decreased compared to wild-type; however phosphorylation in cardiac myocytes is normal

• no other obvious abnormalities are seen in homozygous mice